The Merseyside derby will be played at Goodison Park on June 21 after Liverpool City Council gave the go ahead for Everton and Liverpool to complete their remaining games at home.
Everton are due to host Liverpool when both clubs resume their campaigns in 11 days' time, and the match could see Liverpool claim the Premier League title if Manchester City lose to Arsenal next Wednesday.
That had led to concerns fans could congregate around the ground in breach of restrictions imposed due to the coronavirus pandemic, but following meetings involving the clubs, health authorities, the police and the council, the match has been given the green light.
A statement from the Deputy Mayor of Liverpool, councillor Wendy Simon, said: "We are satisfied that the considerable evidence and guidance provided by the government, Everton and Liverpool Football Clubs, public health colleagues and Merseyside Police will ensure that the outstanding fixtures for the 2019-20 Premier League season can be safely and securely played at both Goodison Park and Anfield.
"A lot of factors have been taken into consideration by the (Ground Safety Advisory Group), especially the safety of the players, match officials and staff in attendance at both stadia.
"We are confident the measures in place will allow the matches to be held behind closed doors without any detrimental impact to all concerned and recommend to the city council that the safety certificates for both grounds be amended to allow this to happen."
The match between Everton and Liverpool is due to be the first Merseyside derby to be broadcast on free-to-air television since the Premier League was launched.