Laugh Out Loud can upset her better-fancied stablemate by stealing the honours in the Coronation Stakes at Royal Ascot.
Trainer Mick Channon fields two in the race with Irish 1,000 Guineas heroine Samitar his clear first string for the Group One event.
However, this looks a tricky contest to judge on paper with question marks over the likes of Newmarket victor Homecoming Queen and even Samitar herself in what is something of a jumble of form.
Laugh Out Loud looks a thoroughly progressive filly though and could be the type to spring a minor surprise after landing a Chantilly Group Two event last time.
Frankel delivered a virtuoso performance in the Queen Anne Stakes on the opening day and it is now time for his brother Noble Mission to step up to the plate in the King Edward VII Stakes. Henry Cecil has always been clear in his assertion that the siblings are totally different types and Noble Mission has always appeared to be more of a middle-distance prospect.
Winner of two of his three starts so far this term, Noble Mission has progressed from an initial maiden win at Newbury to landing Listed honours at Newmarket.
He only narrowly lost out to Thought Worthy at that level last time, being beaten a neck when conceding 5lb.
Minimise Risk is another Derby also-ran who makes a swift return to the fray and he must have a squeak in the Queen's Vase.
A son of Galileo out of a half-sister to such horses as Rewilding and Dar Re Mi, Minimise Risk is bred to excel over 12 furlongs and beyond.
He may lack the pace of a true Group One horse but this two-mile trip should be within his compass for trainer Andrew Balding.