Jonathan Davies has targeted the Ireland half-backs as key to winning a Grand Slam.
The Wales centre knows all about the influence of Conor Murray and Jonathan Sexton from working closely with them for the Lions in 2013 and 2017.
"They have great tacticians at nine and ten and, for us, it is about making sure we do not give them time to take a stranglehold on the game," said Davies.
"Once they do get that foothold there is no-one really better than those two."
In truth, Sexton looked to have recovered his rhythm against France, while Murray is still not quite back to his best.
No matter, Wales know that keeping the Irish playmakers in check will go a long way towards securing a third Grand Slam under coach Warren Gatland, in his final campaign.
"We have to cut their time down and make sure we make them make tackles and become tired, so when it comes to those key decisions they are not as fresh as they would be at the start of the game," added Davies.
"Having played with them, they are two great players.
"We have to be at the top of our game to make sure we do not give them the opportunities to put Ireland into the areas they want to play in."