All Blacks skipper Richie McCaw, who will win his 135th cap on Saturday, believes New Zealand will have an extra motivation beyond accumulating a fifth successive victory over England today.
The first of four QBE Internationals staged at Twickenham this month is the final time the rivals will clash before challenging for the Webb Ellis Cup at England 2015.
And McCaw is determined to issue a declaration of intent ahead of next year's World Cup.
"We've talked a little bit about this being the last time we are here in England playing at a place where hopefully we will get a crack to play at next year," McCaw said. "It will be one hell of challenge against England, but it's something we are excited about."
Halfpenny: Win would be huge
Leigh Halfpenny has warned that Wales will need "to be on the money for 80 minutes" this weekend in their pursuit of a prize that has eluded them for six painful years.
Wales have not beaten a southern hemisphere giant - Australia, New Zealand or South Africa - since November 2008, a run of 20 successive defeats.
While the Twickenham World Cup clash between Wales and the Wallabies is still 11 months away, full-back star Halfpenny says: "We are striving to be the best in the world, and to be that you have got to beat the best. Saturday is an opportunity to do that.
"With the World Cup around the corner and Australia being in our group, to get a win over them would be huge for us."
Buoyed by a first Rugby Championship success at Australia's expense, Argentina have their sights on beating Scotland at Murrayfield for a fifth straight time on Saturday.
Pumas center Marcelo Bosch said: "We have tried to trust more in our system and to take more risks.
"This year, we showed we can do that in some matches, and now we have to reach a level of maturity where we can play with the ball in the good times, but kick it if we have to as well."