Former Scotland fly-half Dan Parks, a late withdrawal last week, returns to the controls for coach Eric Elwood in what should be a four-point gain.
Ireland U20 Robbie Henshaw will start at full-back, pushing club captain Gavin Duffy out to the left wing in place of Fetu'u Vainikolo.
Second row Mick Kearney comes in for Michael Swift to partner Andrew Browne in the engine room behind what is beginning to look like a first choice front row in Nathan White, Jason Harris-Wright and Brett Wilkinson.
Twenty-seven-year-old centre Brian Murphy, who made his Connacht debut in Cardiff last week, holds on as Dave McSharry and Kyle Tonetti are still out of action.
Connacht: R Henshaw; D Poolman, E Griffin, B Murphy, G Duffy (capt); D Parks, K Marmion; B Wilkinson, J Harris-Wright, N White, M Kearney, A Browne, J Muldoon, W Faloon, E McKeon.
Zebre: A Benettin; L Sarto, M Pratichetti, G Garcia, S Sinoti; P Buso, A Chillon; A De Marchi, A Manici, D Ryan, J Sole, M Bortolomai, F Ferrarini, A Bergamasco, A Van Schalkwyk.