Cup finalists 11890 Killester and UCD Marian switch their thoughts to the Nivea For Men's SuperLeague this weekend with games against Bord Gais Neptune and Moycullen respectively.
Belfast Star have two games in the space of two days against UL Eagles and Ulster Elks respectively, while in-form duo DCU Saints and UCC Demons clash in Dublin.
UCD Marian booked their place in the National Cup finals last weekend for the first time, but their head coach Fran Ryan insists there will be no room for complacency as their play-off hopes gather pace away to Moycullen.
"We know this game is hugely important to win in our chase for a play-off spot at the end of season," said Ryan.
Moycullen are still without the services of injured duo Cian Nihill and Garnett Griffin as they look to end their run of seven league games without a win.
11890 Killester will be missing Michael Goj (damaged achilles) as they face their second trip to Cork in a week to face a Bord Gais Neptune side with their sights on the play-offs.
Despite progress in the cup, the Dubliners will be wary after suffering shock league defeats at the hands of DCU Saints and Belfast Star in recent weeks.
"We will be looking to continue our form from last week's win in the cup," said Killester head coach Mark Keenan.
Neptune have been hampered by the injury blow to Ian McLaughlin as they try and close the gap on UCC Demons in the Southern Conference.
UL Eagles have to shake off the disappointment of their semi-final cup defeat to 11890 Killester when they make the trek to Belfast Star.
For Ulster Elks, a derby match-up with Belfast Star is the perfect tonic to help put their cup disappointment behind them.
The Elks were pegged back by UCD Marian, and their task of recovering won't be helped by the news that influential duo, Kevin Foley and Barry Drumm, are both ruled out.
UCC Demons travel to Dublin to face a DCU Saints rejuvenated following excellent displays against 11890 Killester and UL Eagles in their last two outings.
Demons too boast a healthy record, claiming wins in their last three games, to help edge them above Neptune into second place in the Southern Conference.
In the IrishSport.TV Women's SuperLeague, Team Montenotte Hotel Cork head to the capital to face Black Forge Oblate Dynamos, while beaten cup semi-finalists 11890 Killester and Waterford Wildcats meet in Clontarf.