Reigning Nivea For Men's SuperLeague champions 11890 Killester make the trip to UCC Demons in the latest round of fixtures, while UCD Marian will be looking to earn their first win of the season at home to Bord Gáis Neptune.
Elsewhere, UL Eagles entertain Belfast Star and DCU Saints will be looking to build on their opening win of the season against Moycullen.
Darren O'Neill got his reign as head coach of 11890 Killester off to a winning start against Belfast Star but he faces a much tougher proposition away to UCC Demons.
Star were without American Tyson Johnson and Killester's point guard Robbie Clarke knows his side won't have it so comfortable on Leeside.
"UCC Demons are one of the best teams around with Niall Murphy and Carlton Cuff returning and we will need to be on top form this week," said Clarke.
"We might not be as strong or deep as previous seasons but we still have some big names here and will do everything we can to keep the league title we won last season."
Demons head coach, Paul Kelleher, is refusing to believe that Killester are not as strong a force this season after the departure of the likes of Paddy Kelly, John Behan and Michael Goj during the summer.
"Their core is still very much loaded with talent and they have a tonne of experience," said Kelleher. "Darren O'Neill is a top coach so it is a major challenge for us."
UCD Marian are at full strength as they look to bounce back quickly from their disappointing opening weekend defeat away by DCU Saints.
This weekend they face a Neptune outfit, buoyant after their 16-point win over UL Eagles.
In the Nivea Women's Superleague, DCU Mercy bring a full-strength squad to newcomers Ulster Rockets, who suffered an opening day loss to Killester, albeit by a slender 71-62 scoreline.
"They lost last weekend but it shows what they are capable of when you consider they put 62 points on the board against a team like Killester last weekend," said Mercy head coach Mark Ingle.
Killester are sweating over the fitness of Kate Gillen and Caroline Flynn ahead of their derby clash with Meteors.
Their opponents have better news on that front as Katie Kilbride and Susan Fogarty return after missing last weekend's defeat away to UL.
Liffey Celtics will certainly get a taste of the high life this weekend as their second game in the top flight comes against seasoned campaigners Team Montenotte Hotel, while Oblate Dynamos face a daunting test against champions UL.
Nivea for Men Superleague: UCD Marian v Bord Gáis Neptune, UCD Sports Centre, UCD, 7.0.
Nivea Women's SuperLeague: Waterford Wildcats v Singleton's Super Valu Brunell, Mercy Gym, 5.0; Ulster Rockets v DCU Mercy, DLS Anderstown, 6.30; Oblate Dynamos v UL, Oblate Hall, 7.0; Liffey Celtics v Team Montenotte Hotel, Leixlip Amenities Centre, 7.30.
Basketball Ireland Men's Division One: Team Garvey's St Mary's v Matt O'Flaherty Chemist Titans, Castleisland Community Centre, 7.45; Portlaoise BC v Ballon BC, St Mary's Sports Hall, 7.30.
Basketball Ireland Women'S Division One: UL Basketball Club v Team Tom McCarthy's St Mary's, UL Arena, 4.30; Foireann Na Gaillimhe Mystics v Scruffy's St Paul's Killarney, Calasanctius College, 4.30.
Nivea for Men Superleague: UCC Demons v Killester, Parochial Hall, 3.15; UL Eagles v Belfast Star, UL Arena, 3.30; DCU Saints v Moycullen, DCU Sports Complex, 3.30.
Nivea Women's SuperLeague: Meteors v Killester, Coláiste Eoin/íosagáin, 3.0.
Basketball Ireland Men'S Division One: Blue Demons v Team Meadowlands St Brendan's, Parochial Hall, 1.0; Neptune v Team Left Bank Kilkenny, Neptune Stadium, 2.0; Maree v Team Loftus Recycling Ballina, Calasanctius College, 3.0.