Some 185 new jobs have been announced in a series of investments by companies involved in technology, finance, medical devices and business analytics.
Six firms from North America and Europe will set up new offices and take on extra staff over the next two to three years in expansions backed by enterprise agency, IDA Ireland.
US-based NuoDB, which provides database technology, is to hire 50 people as it sets up a development centre in Dublin and an office in Belfast, with developers, engineers and tech support professionals being hired over the next three years.
Three companies are taking on 30 staff each - Artisan Infrastructure, an IT firm, is to set up a HQ in Dublin; as is New York firm Modern Marketing Concepts, which specialises in optimising sales; while software developer DataClarity is to expand its operations.
Medical devices manufacturer CRI, is to expand its operations in Wexford over the next three years, with the additional production designed to support its facilities in Costa Rica, as well as Indianapolis and Minnesota in the US.
Another 20 jobs are to be created by Megatransfert SAS, a small but fast growing-company headquartered in Nice, France, which specialises in micropayments via prepaid cards and other finance technology solutions including converting phone credit to cash.
Jobs Minister Richard Bruton said the investments were a result of high-growth companies being targeted by the IDA.
"The thinking behind this drive is that these companies will establish deep roots here from early in their growth and make a substantial impact on our economy," he said.
"There is also of course the possibility that one of these companies will turn into a world-leading company of the future."