Surgeons are celebrating after a father successfully received a kidney from his daughter -- despite them having different blood groups.
Mark Trimby (47) an engineer from Bristol, had the organ transplant from his daughter Carly (24) using a new technique pioneered in Japan.
The operation offers hope to more patients with advanced kidney failure. The procedure removes the blood's anti- bodies, which could prevent a successful transplant.
Blood group incompatibility between donor and recipient used to be considered an absolute biological veto against proceeding to transplantation.
After suffering for more than 10 years with chronic kidney disease, Mr Trimby's condition worsened considerably around 12 months ago. Doctors told him he needed a new kidney and he was put on dialysis.
His wife came forward as an organ donor but was ineligible because she had kidney stones.
Carly also volunteered but, she had blood group A and dad Mark was group O.
Carly said: "My dad's condition was really deteriorating by this point and he had to endure hours of dialysis each week. Donating my kidney to my dad was something I really wanted to do."
The new procedure involved giving an extra anti-rejection drug (Rituximab) to help switch off the cells in Mark's body that generate anti-blood group A antibodies plus a treatment called plasma exchange, which removes the antibodies that are already present in Mark's blood.