herald

Thursday 16 August 2018

Chemical found to stop cancer spreading

Blocking a key chemical can stop breast cancer spreading to other organs, experts have discovered.

Scientists at The Institute of Cancer Research (ICR) have found, for the first time, that a particular enzyme is involved in the spread of tumour cells from the breast to other parts of the body.

If experts can successfully block the action of lysyl oxidase-like 2 (LOXL2), then treatments could be developed to stop the spread of breast cancer.

Recent studies have shown that the lifetime risk of the disease for women is now one in eight. Experts blamed lifestyle factors, including obesity and drinking alcohol, for fuelling the rise.

Women are also more likely to have children later in life and fewer offspring, which influences the risk.



proteins

In the latest study, published in the journal Cancer Research, experts found that LOXL2 promotes the spread of breast cancer through the way it controls two proteins, TIMP1 and MMP9.

Scientists found that blocking LOXL2 decreased the spread of breast cancer to the lungs, liver and bone.

According to lead researcher Dr Janine Erler, from the ICR, more than 90pc of cancer deaths are because the disease has spread to other organs.

"Our study shows that inhibiting the action of LOXL2 can significantly reduce the spread of breast cancer, suggesting that drugs which block this enzyme may be effective in preventing patients' cancer from spreading," she said.

hnews@herald.ie

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