Florence + The Machine will headline the Friday night slot at Glastonbury after the Foo Fighters were forced to pull out over frontman Dave Grohl's broken leg.
Emily Eavis, the daughter of festival founder Michael Eavis, said: "So happy Florence is going to step up to headline Friday night, she's going to smash it!"
Grohl apologised to fans after his accident forced the band to cancel a string of gigs, including Glastonbury and Wembley.
He injured himself after falling off stage during a concert in Sweden last week.
As well as their appearance on Glastonbury's Pyramid Stage, the veteran rock band - who played Slane Castle last month - have also scrapped gigs at Wembley Stadium this Friday and Saturday and Murrayfield in Edinburgh on June 23.
In a message on the band's website Grohl (46) wrote that he had flown to London for surgery and had six metal pins inserted in his leg after "dropping about 12 feet, dislocating my ankle and snapping my fibula like an old pair of take-out chopsticks".
"The most important thing now is for me to recover from the surgery, to keep my leg elevated so as to keep swelling down and prevent any infection/complication that could do long-term damage.
"I'm not out of the woods yet, folks," he added.