American student Amanda Knox broke down as details of the wounds inflicted on her alleged murder victim were read out in court.

Knox, accused of fatally stabbing her roommate in Italy, had a growing hatred for the victim and killed her in retaliation during a drug-fuelled sex game, her murder trial heard.

Lead prosecutor Giuliano Mignini argued that Knox, together with her ex-boyfriend Raffaele Sollecito, killed Meredith Kercher under "the fumes of drugs and possibly alcohol".

Knox -- also know by the nickname 'Foxy Knoxy' -- and Sollecito (25) tried to cover up their crimeby staging a burglary, he contended. Knox, from Seattle, wanted to get back at Kercher for saying she was not clean and for calling her promiscuous, Mignini argued.

"Amanda had the chance to retaliate against a girl who was serious and quiet," Mignini said.

"She had harboured hatred for Meredith, and that was the time when it could explode. The time had come to take revenge on that smug girl."

Knox (22), who has denied wrongdoing, wept as Mignini described the wounds on Kercher's body.

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Her lawyer, Luciano Ghirga, sitting next to her, at one point held her hand. Looking discouraged and keeping her head down, she was hugged and comforted by lawyers during breaks.

Mignini recalled previous testimony by Kercher's friends, in which she reportedly expressed surprise and irritation at Knox's behaviour. Knox has denied having major problems with Kercher and has said in the past she was shocked at the death of a woman she considered a friend.

Knox and Sollecito are charged with murder and sexual violence in the 2007 killing in the central Italian town of Perugia. Sollecito also maintains he is innocent.

Ivory Coast citizen Rudy Hermann Guede is appealing his conviction and 30-year sentence handed down after the fast-track trial he requested.

Mignini contended that Knox, Sollecito and Guede met at the apartment where Kercher was killed on November 1, 2007, shortly before the slaying, probably to settle some drug issues with Guede, who was known in Perugia for dealing drugs.

According to the prosecutor, Kercher and Knox started arguing and then the three brutally attacked the Briton.

Kercher's body, her throat slit, was found in a pool of blood the next day.

Occasionally raising his voice during his seven hour-long argument, Mignini described what he called "an unstoppable crescendo of frenzied violence," which began with Knox and Sollecito trying to take off Kercher's clothes and threatening her.

At one point, Knox hit Kercher's head against a wall, then tried to strangle her, as Sollecito held her and Guede sexually assaulted her, Mignini alleged.

"They realised that Meredith would not give up fighting and at that point, the match had to be brought to an end," he said.

Mignini said Knox used a knife to cut Kercher's throat, causing the deepest wound, while Sollecito used another knife to threaten her.

According to prosecutors, a knife with a six-and-a-half-inch blade with Kercher's DNA on the blade and Knox's on the handle was found at Sollecito's house.

"That is the weapon with which Amanda inflicted the deadly blow," Mignini said.

Defence lawyers argue that the knife is too big to match Kercher's wounds and the amount of what prosecutors say is Kercher's DNA is too low to be attributed with certainty.

Prosecutors also claim Sollecito's DNA was found on the clasp of Kercher's bra, although his defence team contends that the evidence might have been inadvertently contaminated during the investigation.

Yesterday, Mignini said that Knox and Sollecito staged a burglary in the apartment by breaking a window in a bedroom in an attempt to sidetrack the investigation.

A rock was found in a bedroom, and witnesses testified that shattered glass was found all over clothes on the floor, suggesting the window was broken after the room was put into disarray.

"The key to the mystery is in that room," Mignini said, adding that it would be nearly impossible to climb through the window without getting cut and leaving blood on the shattered glass.

Also, he argued, that window, the most exposed of the apartment, was an unlikely choice for a burglar. Nothing in the room with the broken glass, which belonged to a roommate of Knox and Kercher, was reported missing, Mignini noted.

"All of this was done to channel suspicions on a stranger, and divert them from those who had the apartment keys," he said.

Knox's defence lawyer Carlo Dalla Vedova said Mignini's reconstruction was "suggestive," but it failed to present solid evidence.

Prosecutors were expected to formally make their sentencing requests to the eight-member jury today, while a verdict is expected early next month. They are expected to request life in prison -- Italy's stiffest punishment.

Knox maintains she spent the night of the murder at Sollecito's house in Perugia.

Sollecito has said he was home working at his computer that night. He said he does not remember if Knox spent the whole night with him or just part of it.

Defence lawyers for Knox and Sollecito are working on the theory that Guede was the sole attacker.

hnews@herald.ie

- Marta Falconi