The build-up to the capital derby has been dominated by the personalities of Redknapp and Villas-Boas, the former Chelsea manager who succeeded him at White Hart Lane and has since guided the club to third place.
Redknapp's departure ended a tumultuous period in his life in which he overcame heart surgery, was cleared of tax evasion, became favourite to coach England before missing out to Roy Hodgson and was linked with Chelsea and then fired by Spurs .
Having masterminded Tottenham's fourth-placed finish in the Premier League, the 65-year-old now finds himself repairing the damage incurred by Mark Hughes' failed regime at QPR, but there is no sense of bitterness.
"I don't have a relationship with Villas-Boas but then I don't have a relationship with any other manager in the Premier League," Redknapp said.
"I don't socialise with him, he's gone to Tottenham and done a great job. What's the problem? I've got no problem with him at all.
"If I had something bad to say about him I'd say it, but I don't know him. I'll shake his hand after the game and invite him in for a drink, whatever the result. I don't have any problems with him. He seems a nice guy."