The Senegal international gave the Magpies a second-minute lead over Everton with his sixth goal of the season as compatriot Demba Ba closed in on his move to Chelsea last night.
However, it was not enough to prevent his side from slipping to a ninth defeat in 11 Premier League games as the visitors hit back to snatch a 2-1 win.
Pardew has challenged Cisse to rediscover the touch which brought him 13 goals in 14 appearances following his arrival 12 months ago.
Asked if the former Freiburg frontman was relishing the role of main man, he said: "I think so, and we are hoping he has the second half of the year he had last year.
"That's where we need to get him."
Newcastle could have gone in at the break with a commanding lead having forced their way ahead through Cisse's looping header.
They went close to a second when James Perch's header came back off the inside of the post on the half-hour, but worse was to follow two minutes before half-time.
Fabricio Coloccini was harshly adjudged to have fouled Marouane Fellaini 30 yards out, but Leighton Baines was merciless as he smashed home the resulting free-kick.
Where there had been little to choose between the sides before the break, it was the visitors who dominated after it and they got their reward on the hour when Victor Anichebe, who had only been on the pitch for two minutes, turned Nikica Jelavic's cross past keeper Tim Krul.
Pardew, who hopes to clinch the signing of Lille full-back Mathieu Debuchy during the next 48 hours -- the France international was among the crowd for last night's game -- has been forced to contend with a crippling injury crisis, and a fixture list which sent his side to Manchester United and Arsenal before their clash with the high-flying Toffees.
He said: "There's no doubt that when we get our best side out, we are a quality team, but we haven't had it all year and we can't expect to have it out. We need to get as many as we can out and start winning games."