Bolstered by the return from injuries of Ospreys prop Adam Jones and Exeter tighthead Craig Mitchell, the scrum is an area where Wales should be noticeably stronger than during this season's autumn Tests when they lost all four games.
"We would like to think going into this campaign that our scrum can be used as an attacking weapon," Wales defence coach Shaun Edwards said.
"Adam, in particular, is a big weapon come scrum-time. In last year's Six Nations our scrum was a big weapon for us, so hopefully that will return."
Wales failed to establish themselves in the scrum battle against either Argentina or Samoa two months ago, and Edwards also believes it is essential the referee's instructions are grasped far more quickly.
Frenchman Romain Poite refereed the Argentina game, and he will also be in charge when Wales kick off their campaign against Millennium Stadium visitors Ireland next Saturday.
"There is no doubt in those first two games (of the autumn), the scrum was an issue," Edwards added.
"It is very important we learn from that game, and that we have to listen to Romain Poite."
Wales' interim head coach Rob Howley is due to name his starting line-up on Thursday, with Dan Biggar a firm favourite to replace injured fly-half Rhys Priestland, and fitness permitting, the second-row partnership is pointing towards Ospreys pair Ryan Jones and Ian Evans.
Wales are already without injured locks Alun-Wyn Jones, Luke Charteris and Bradley Davies.
Should Jones or Evans, or both, be ruled out of contention to face Ireland, then a selection door would probably open for uncapped locks like James King, Andrew Coombs and Harlequins' Olly Kohn.
Wales have not beaten another Test-playing country since defeating France to clinch the Six Nations title and a third Grand Slam in eight years at the Millennium Stadium last March.