O'Driscoll, who recently turned 34, is Ireland's record caps holder (120) and try scorer (45), but he has previously only suggested that he would not extend his career to the next World Cup, to be held in 2015.
He is still anxious to secure an extension to his IRFU contract, but he has now revealed for the first time that he may be willing to complement fast-forwarding his retirement date.
"There's every chance (it could be my last Six Nations)," he said. "I haven't really allowed myself to think about it. I am contracted until the summer. I'll see that out and then I'll see how the body feels. But there's a strong possibility that this could be the last."