Named in 2005 as one of five rising stars in the Democratic Party, along with Barack Obama, he is now Governor of Maryland.
He will visit the Dublin Chamber of Commerce on Tuesday to speak about the power of good government.
The Wire was set in Baltimore when it had one of the highest murder rates in the US.
Creator David Simon has insisted the fictional Mayor Carcetti is not O'Malley, but admitted he was one of several sources of inspiration.
O'Malley appeared in the film Ladder 49 playing himself as the mayor.
The 2004 movie starred John Travolta and Joaquin Phoenix and told the story of a Baltimore firefighter trapped in a warehouse fire and his recollections of how he got there.
O'Malley also played in several rock bands and was the vocalist/guitarist/songwriter of Celtic rock band O'Malley's March from 1988 to 2005.
He also featured in the History Channel's First Invasion: The War of 1812 about the British attack on Baltimore in 1814.
In 2002, at 32, Esquire named O'Malley best young mayor in the country, and in 2005 Time named him one of America's 'Top 5 Big City Mayors'.
First elected Mayor of Baltimore in 1999, he was re-elected in 2004.
He was elected Maryland governor in 2006 and was re-elected in 2010.
Under O'Malley, Maryland was ranked first in the US for entrepreneurship and innovation by the US Chamber of Commerce.