The U2 bandmates have pumped significant investment into the company.
And now the company, which has been dubbed as 'the next Apple', said that it will create between 30 and 40 jobs in Ireland in the new year.
Bono and the Edge got to know the Dropbox founders after they developed a music app on Facebook, iLike, a precursor to Dropbox.
The American founders approached U2 to help them with the launch of the new feature which would help them promote videos to fans.
The storage service, which now counts a massive 100 million registered users, will be a massive boost to the tech industry in the capital.
Dublin is also home to web tech groups Google, Facebook, Twitter, Ebay and LinkedIn.
Full details of the job opportunities have not been unveiled at this stage although Dropbox's Dublin office is expected to hire for a variety of positions, including multi-lingual sales teams, account management and user operations staff, all of which will provide targeted support to the millions of Dropbox users in Europe.
The company is actively hiring for a range of positions, including account executives, account managers, IT engineers and user ops engineers.
Dropbox recently added Italian and European Spanish to the range of languages that it covers, and the company says that the new office will help expand that linguistic support while ensuring that business users and other paying customers outside of North America will have local sales and staff available to help "at nearly all hours of the day."
Dropbox was founded in 2007 and is based in San Francisco.
The company offers a simplified form of cloud technology, allowing users to save files including images and music in a remote location.
Over one-third of Dropbox users are in the European region alone and Dropbox's new office opening comes at an ideal time to support the company's immense growth and expansion, Drew Houston, CEO and co-founder of Dropbox said.
"By opening our international headquarters in Dublin and tapping into the large talent pool that exists there, we're better positioned to serve even more people locally while we continue to grow."
The investment was supported by the IDA. Taoiseach Enda Kenny said that it was an indication that Ireland was ready to usher in the next generation of internet firms.
"Ireland has many advantages to offer international companies, including our young, passionate and talented workforce, all of which will be a great asset to Dropbox as they make their new home in Dublin," he added.