From a sweaty breakthrough in Grisham's A Time to Kill, right through to pec-flexing theatrics in Sahara, How to Lose a Guy in Ten Days and the Wicklow-shot Reign of Fire, the McConaughey upper physique is essentially better known than its tag- along face.
And now, the long neglected, pert posterior is headlining an all-star revue in stripper saga, Magic Mike.
In a G-string, no less.
Even this may have been a step too far for the 42-year-old Texan.
"It wasn't so much baring the flesh," he smoothly drawls, in London's Claridges Hotel.
"But stripping down to a thong is a little different, I don't care what shape you're in. There's something where you're thinking, 'Are you kidding me?' It's a thong ... even the word is weird to say."
As Dallas, described by the star as 'the MC host and capitalist Messiah of the male stripper universe', McConaughey delivers a scene-stealing turn as leather-pant rocking, top dog of the Xquisite dance club, where Magic Mike (a suitably ab-tastic Channing Tatum) and his buff cohorts, newcomer Alex Pettyfer and True Blood's Joe Manganiello, perform their racy routines.
Loosely based on Tatum's personal experiences, the movie's creating quite the frenzy at the box office and early Oscar buzz for Matthew's deluded purveyor of sin.
"Dallas isn't a part that would normally attract that kind of attention. I wanted to play him really committed, really straight, no wink.
"He is dead serious about what he does, there's nothing funny or camp about it at all."
For his own lengthy strip sequence, featuring aforementioned thong, the actor, who recently tied the knot with long-term partner, Camilla Alves, admits he adopted our, apparent, 'feckless' attitude encountered here while filming fantasy epic Reign of Fire in Dublin nearly 11 year ago.
"You guys just don't give a shit," he says.
"You're not afraid to take a risk. When I was staying at the Morrison while shooting Fire, I used to go walkabout to these old pubs where I met the most inspiring people, who'd sing and perform and tell stories.
"I picked up my favourite phrase that I still use now, 'ye lunatic' from one of those pubs and I had that going through my head while shooting the strip scene in Mike.
"It was this idea of 'f**k it', which you guys are all about, that got me through. You know, I can't wait to get back to Ireland again." That shouldn't be too long considering the dad of two, with another on the way, has been in close talks with Jim Sheridan for years about working together.
"I'm always meeting Jim at the Chateau Marmont in Hollywood," he says.
"It's been this thing where we've been speaking about doing something together for years.
"I know he was working on a script for Emerald City, this Irish American gangster movie, something I'd be very interested in but whether that's going ahead, I don't know.
"Jim's high on my wishlist, Neil Jordan, too.
He adds: "I just want to get back to Ireland, I feel very comfortable there, naturally because I'm Irish myself but with the young family right now, I could only come back if it was for work. I'm open to offers. Hell, a remake of one of the classics, Ryan's Daughter, The Quiet Man, now those are scripts I'd like to read."
Once the romcom king, thanks to fluffy hits like Failure to Launch and The Wedding Planner, Matthew admits he's intentionally pursuing a change in career trajectory.
Recent mind-bending release Killer Joe saw him take on an uncharacteristic psychotic turn, while upcoming Cannes favourites Mud and The Paperboy show us that he's not just a pretty pair of abs.
"I kept getting action scripts, adventure scripts, comedy scripts and all of them, I've kind of done before.
"So I took some time out, maybe a year and a half, and I started to get different calls for different scripts.
"All these directors like William Friedkin called, Lee Daniels called, something switched because I said 'no' to doing other things.
"Now it feels different, a good different, so I won't go back to that territory again unless I find something that really turns me on."
Magic Mike is in cinemas now