However, it will be the familiar face of Pat Kenny who returns to the hotseat tomorrow night.
Tubridy has taken the rest of the week off from his RTE duties after confirming that his father, Dr Patrick Tubridy (76), passed away peacefully yesterday in St Vincent's Private Hospital after a short illness.
A notice issued today said that his death brought "inexplicable grief" for his beloved wife and best friend Adele and their two beautiful daughters Eloise and Molly, and his children Judith, Niall, Rachel, Ryan and Garrett.
The funeral of the former consultant psychiatrist will take place tomorrow in John the Baptist Church in Blackrock.
RTE released a statement expressing its "sincere sympathies" to Ryan Tubridy and his family on their loss.
It also issued a message from the broadcaster himself expressing his "sincere thanks" for the support and messages the family had received, and requesting privacy.
"Ryan was extremely close to his dad and very upset losing him," said a friend of the broadcaster.
Tubridy's friend Dave Fanning has stepped into the breach at his 2fm radio programme, while Pat Kenny has been asked to make a return to the Late Late Show, which he hosted for 10 years.
The last time the programme had a stand-in host was in October 2008 when Pat Kenny's mother Connie passed away and the late Gerry Ryan presented the show.
Original host Gay Byrne never missed a Friday night during his 37-year tenure as host.