The fast-talking presenter has revealed how their world-renowned track One emerged victorious after a long-running poll among his listeners to find their favourite hit.
In Fanning's Fab 50, the foursome managed to beat off competition from some strong contenders to come out on top.
Other anthems in the final included Kings of Leon's Sex On Fire, Led Zeppelin's Stairway To Heaven and The Killers' hit Mr Brightside.
But our own Dublin lads claimed three of the top ten places with One, Bad and With or Without You.
Now in it's 29th year, Fanning's poll has been calling on his listeners to name their favourite all-time hits over the past few weeks.
U2 have always dominated Fanning's Fab 50 with One in particular topping the charts over the past few years, said Dave.
"I've seen them been challenged from the likes of Nirvana, Smashing Pumpkins, The Smiths and Radiohead but, regardless, U2 are always there or thereabouts. Every year, the top ten has featured numerous U2 tracks and yet again it's great to see that their following in Ireland is as strong as ever."