Binoche will be at a screening of her film, Another Woman's Life.
Binoche launched her international career in The Unbearable Lightness of Being alongside Daniel Day-Lewis.
Having won an Oscar for The English Patient, she also starred in the 2000 classic, Chocolat, with Johnny Depp.
In Another Woman's Life, she plays Marie, who has woken up to find she has forgotten the last 15 years of her life.
And the exciting romance that she remembers appears to have resulted in a son and a marriage, which is now heading for divorce.
Also in attendance will be Beatrice Dalle, best known for her starring role in the 1986 cult classic Betty Blue.
Dalle will be the guest of honour at the director's cut screening of Betty Blue.
She'll also present her latest film, Bye Bye Blondie, which tells the story of an erratic and passionate love affair.
Dalle plays installation artist Gloria, who is reunited with former lover and now TV host, Frances (played by Emmanuelle Beart) after years of being apart.
Told in flashbacks, the film recounts the passionate affair of the two women who first met in a psychiatric hospital.
Directed by Virginie Despentes, (Baise-Moi), the films has already been hailed by critics. Dalle will also be participating in a Q&A session after the screening of Bye Bye Blondie.
Both Bye Bye Blondie and Betty Blue will be shown on Saturday, November 17, while Another Woman's Life will be screened the following Saturday, November 24.
The film festival opens tonight (November 14) with the Irish premiere of Love by Michael Hanke and runs until Sunday November 25.