The abandoned house will be bulldozed, along with two other houses on the site, to make room for the 43 new apartments due to be built by Boheranch Ltd, which have been given the go-ahead by Navan Town Council.
The company's earlier plans for the riverside site had been rejected three times by the town council, who first refused planning permission for the building work in 2004.
Two more applications followed between 2004 and 2008, with residents voicing concerns about the visual impact on the Boyne, and traffic implications.
Inspector Brian Brannigan backed the council's decision to refuse permission.
The original proposal was for 71 apartments and 25 office units on a 0.57 hectare (1.4 acre) site, but was subsequently amended to include three blocks accommodating a total of 43 apartments.
Navan vet Michael Carolan, who was one of the primary objectors to the application, said the decision marked a sad day for the people of Navan.
"It's sad because Pierce Brosnan is one of the most famous people to come out of this town and once his house is demolished it will be the last trace of him gone," he said.
Brosnan's parents -- carpenter Thomas Brosnan and his mother May, a nurse -- split up when he was a young child, leaving his grandparents Philip and Kathleen Smith to raise him in May's family home in Navan.
Brosnan has previously described his childhood as very solitary and claims he never knew his father at all.
"He left when I was an infant and I was left in the care of my mother and my grandparents," the actor said.
"My mother was very courageous. She took the bold steps to go away and be a nurse in England, basically wanting a better life for her and myself.
"My mother came home once a year, twice a year."
The actor later moved to London to join his mother and subsequently studied acting before going on to become a worldwide phenomenon.